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KMID : 0043320050280050509
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Archives of Pharmacal Research
2005 Volume.28 No. 5 p.509 ~ p.517
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Synthesis, Analgesic, and Anti-Inflammatory Activities of [6-(3,5-Dimethyl-4-Chloropyrazole-1-yl)-3(2H)-Pyridazinon-2-yl]Acetamides
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Murat Sukuroglu
Burcu Caliskan Ergun
Serdar unlu
M. Fethi Sahin
Esra Kupeli
Erdem Yesilada
Erden Banoglu
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Abstract
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A series of structurally diverse amide derivatives of [6-(3,5-dimethyl-4-chloro-pyrazole-1-yl)-3(2H)-pyridazinone-2-yl]acetic acid were prepared and tested for their in vivo analgesic and anti-inflammatory activity by using p-benzoquinone-induced writhing test and carrageenan-induced hind paw edema model, respectively. The analgesic and anti-inflammatory activity of the compounds, 7c, 7d and 7k were found to be equipotent to aspirin (as an analgesic) and indometacin (as an anti-inflammatory drug), respectively. The other amide derivatives generally resulted in lower activity on comparision with reference compounds.
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KEYWORD
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Pyridazinone, Pyrazole, Analgesic, Anti-Inflammatory, Writhing, Carrageenan
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